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superparamagnetic iron oxide particles uspio molday ion  (BioPAL Inc)

 
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    BioPAL Inc superparamagnetic iron oxide particles uspio molday ion
    Superparamagnetic Iron Oxide Particles Uspio Molday Ion, supplied by BioPAL Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 90 stars, based on 1 article reviews
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    superparamagnetic iron oxide particles uspio molday ion  (BioPAL Inc)
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    Superparamagnetic Iron Oxide Particles Uspio Molday Ion, supplied by BioPAL Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    (A) BOLD (top) and CBV t-score functional maps obtained at two different doses of MION (middle: 20 mg/kg; bottom: 30 mg/kg) in response to a 4 s stimulus duration. Robust BOLD and CBV activations were observed in S1, S2 and caudate. However, caudate showed no CBV activation at either dosage of MION. (B) Mean BOLD HRF (top graph) and mean CBV HRFs obtained with the lower dose (middle graph) and the higher dose of <t>USPIO</t> (bottom graph), in response to a 4 s stimulus, averaged across all five subjects. A stronger CBV response was observed at the higher dose of 30 mg/kg. Error bars = 1 std. dev. *P < 0.05.
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    (A) BOLD (top) and CBV t-score functional maps obtained at two different doses of MION (middle: 20 mg/kg; bottom: 30 mg/kg) in response to a 4 s stimulus duration. Robust BOLD and CBV activations were observed in S1, S2 and caudate. However, caudate showed no CBV activation at either dosage of MION. (B) Mean BOLD HRF (top graph) and mean CBV HRFs obtained with the lower dose (middle graph) and the higher dose of <t>USPIO</t> (bottom graph), in response to a 4 s stimulus, averaged across all five subjects. A stronger CBV response was observed at the higher dose of 30 mg/kg. Error bars = 1 std. dev. *P < 0.05.
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    (A) BOLD (top) and CBV t-score functional maps obtained at two different doses of MION (middle: 20 mg/kg; bottom: 30 mg/kg) in response to a 4 s stimulus duration. Robust BOLD and CBV activations were observed in S1, S2 and caudate. However, caudate showed no CBV activation at either dosage of MION. (B) Mean BOLD HRF (top graph) and mean CBV HRFs obtained with the lower dose (middle graph) and the higher dose of <t>USPIO</t> (bottom graph), in response to a 4 s stimulus, averaged across all five subjects. A stronger CBV response was observed at the higher dose of 30 mg/kg. Error bars = 1 std. dev. *P < 0.05.
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    (A) BOLD (top) and CBV t-score functional maps obtained at two different doses of MION (middle: 20 mg/kg; bottom: 30 mg/kg) in response to a 4 s stimulus duration. Robust BOLD and CBV activations were observed in S1, S2 and caudate. However, caudate showed no CBV activation at either dosage of MION. (B) Mean BOLD HRF (top graph) and mean CBV HRFs obtained with the lower dose (middle graph) and the higher dose of USPIO (bottom graph), in response to a 4 s stimulus, averaged across all five subjects. A stronger CBV response was observed at the higher dose of 30 mg/kg. Error bars = 1 std. dev. *P < 0.05.

    Journal: NMR in biomedicine

    Article Title: Investigation of the BOLD and CBV fMRI responses to somatosensory stimulation in awake marmosets ( Callithrix jacchus )

    doi: 10.1002/nbm.3864

    Figure Lengend Snippet: (A) BOLD (top) and CBV t-score functional maps obtained at two different doses of MION (middle: 20 mg/kg; bottom: 30 mg/kg) in response to a 4 s stimulus duration. Robust BOLD and CBV activations were observed in S1, S2 and caudate. However, caudate showed no CBV activation at either dosage of MION. (B) Mean BOLD HRF (top graph) and mean CBV HRFs obtained with the lower dose (middle graph) and the higher dose of USPIO (bottom graph), in response to a 4 s stimulus, averaged across all five subjects. A stronger CBV response was observed at the higher dose of 30 mg/kg. Error bars = 1 std. dev. *P < 0.05.

    Article Snippet: An initial dose of 20 mg/kg of 30 nm (USPIO) particles (Molday ION, Biophysics Assay Laboratory, Inc., Worcester, MA) was injected to the animals intravenously.

    Techniques: Functional Assay, Activation Assay